DNA analysis determined the AZF microdeletion mutation on the Y chromosome
What is AZF?
AZF (Azoospermia Factor) is a region of the Y sex chromosome, containing many genes related to sperm production and reproduction. AZF is divided into three parts:
- AZFa: No sperm in semen - Simple Sertoli syndrome
- AZFb: No sperm in semen - Sperm cannot mature
- AZFc: Low sperm density
When the AZF deletion mutation occurs, it is necessary to perform tests to check which regions are affected, because each mutation region has a different effect.
..
Morals of expanded AZF test
Testing to identify mutations in the AZF region helps doctors determine the cause of male infertility cases, orienting clinicians for treatment and finding appropriate solutions for patients. Determining the correct cause for treatment will reduce the cost of medical treatment as well as unnecessary costly interventions.
.
Who should take expanded AZF test?
- Men have no sperm in their semen or the sperm concentration is too dilute (less than 15 million sperm/1ml of semen).
- Men before surgery to remove varicocele
- Men do not have sperm in their semen
- A male relative in the family has the AZ gene mutation
.
Expanded AZF test at Phacolab
- Testing method: PCR technique and electrophoresis
- Sample: Whole blood
- Time for results: 03 days from the time of receiving the sample
.
