Why do men need to care about sperm DNA fragmentation?
The rate of infertility in modern society is increasing day by day as a big shock for couples and also a challenge for the obstetrics and gynecology industry. Among the many causes of infertility in couples, 30% of infertility cases come from men. Male infertility is an increasingly common condition, causing many men to have low self-esteem and affecting family happiness.
There are many causes of infertility in husbands. According to statistics from the Hanoi Medical University research group, 15 - 25% of male infertility cases are related to sperm DNA fragmentation. Sperm DNA fragmentation is a condition in which the DNA chain is broken into small fragments, causing genetic abnormalities in the sperm, and affecting the ability to fertilize the egg. The cause of sperm DNA fragmentation can come from an unhealthy lifestyle, toxic environment, age, or disease...
The rate of sperm DNA fragmentation is considered abnormal when the ratio of broken sperm compared to the total number of sperm is greater than 15%. The higher the rate of sperm fragmentation, the more it affects fertility. Not only does it cause infertility and difficulty in fertilization in men, but sperm DNA fragmentation also puts the fetus at risk of miscarriage, and the fetus is at risk of miscarriage. Deformities due to faulty genes.
Therefore, sperm DNA fragmentation testing helps to know the genetic status of sperm, increases the rate of creating healthy embryos in IVF cases, and minimizes genetic abnormalities of the fetus in natural fertilization cases. and artificial insemination.
Modern "gold standard" in sperm DNA fragmentation
Previously, fertility centers were familiar with semen testing (fresh sperm was placed on a glass slide, the technician would examine and evaluate the mobility, density, and morphology of the sperm). However, this method can only evaluate the external morphology and cannot analyze deeply at the genetic level to evaluate the true "health" of the sperm.
On the other hand, sperm DNA fragmentation testing using traditional methods (sperm staining) depends heavily on the skills of the technician. Therefore, the test using Flow Cytometry technology is considered the gold standard in evaluating sperm DNA fragmentation.
Currently, Phacogen Factory has launched the sperm DNA fragmentation test kit PCG® Sperm DNA Fragmentation Kit, developed based on Flow Cytometry technology, which is being widely introduced in hospitals and testing centers, IVF center.
PCG® Sperm DNA Fragmentation Kit is manufactured according to IVD standards and the medical device quality management system is according to EN ISO 13485:2016 standards. Product with many outstanding advantages: simple operation; Implementation time is only 2-3 minutes/test, 2-5 times faster than the time taken by traditional methods.
Besides, the results are highly accurate due to data collected on a large number of sperm (5,000 sperm) and analyzed using specialized software. In addition, the kit comes with a sperm preservation solution, making it easy to store and preserve sperm, and can be used for both "fresh" and frozen sperm.
Phacogen Medical Pharmaceutical Joint Stock Company, formerly known as Biomedic Scientific Materials Joint Stock Company, was established in 2008, as a pioneer in providing molecular biotechnology solutions in diagnostic testing and assessment. criminal science, life science, and agriculture. After 15 years of development, Phacogen has become a large-scale medical corporation with increasingly perfect solutions in the above technology fields.
Phacogen factory, built in Vietnam - Singapore industrial park (VSIP Bac Ninh), is invested in modern production lines according to American and European standards. Phacogen factory specializes in manufacturing test kits that meet EN ISO 13485:2016 and CE - IVD standards.
