Many people believe that children conceived through in vitro fertilization (IVF) will not be at risk of birth defects, because they are made up of selected eggs and sperm. But that is not the case, "vitro fertilization babies" are still at risk of birth defects for many different reasons.
The special thing is that "Vitro fertilization babies" can be born healthy if they are screened for birth defects right from the embryo stage using the PGT method.
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WHAT IS PGT?
PGT (Prenatal Genetic Technology) is genetic testing of embryos before implantation into the uterus, including PGT - A test or PGS (Prenatal Genetic Screening) and PGT - M test or PGD (Prenatal Genetic Diagnostic).
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WHAT DEFECTS DOES THE PGT - A/ PGS TEST SCREEN FOR?
PGT-A/PGS screens for genetic abnormalities related to common syndromes caused by mutations in the number of embryo chromosomes, helping to select healthy embryos before implantation into the mother's uterus.
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PGT – A/ PGS is indicated when:
+ Mothers get pregnant when they are 35 years old or older
+ There is a history of multiple miscarriages
+ Repeated IVF failures
+ Severe male infertility
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WHAT DEFECTS DOES THE PGT - M/ PGD TESTING SCREEN FOR?
PGT – M/ PGD helps detect single-gene genetic defects in embryos, especially meaningful in assessing embryo quality before implantation into the uterus.
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PGT – M/ PGD is indicated when:
+ With single-gene disorders where the dominant trait is known
+ Traits caused by recessive genes
+ X-linked disorders
+ Mutation barrier
+ Human leukocyte antigen (HLA) combination
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WITH WHAT TECHNOLOGY IS PGT PERFORMED?
PGT tests can be performed on many different technologies and generations of technology such as: FISH, Array - CGH, PCR, NGS... Of which, NGS (New Generation Sequencing) is currently the advanced technology. The most advanced, bringing many outstanding advantages:
+ Can test more than 100 million points/set of chromosomes
+ Sensitivity up to 100%
+ Gives results with high accuracy: 99.9%
+ Increase the rate of implantation, pregnancy and live birth
+ Reduce miscarriage rate
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